Mycoplasma genitalium positive always can’t be cured, the main consideration is related to improper medication, poor prognosis, etc., and this disease has the possibility of recurrence. Patients should use reasonable medication, strengthen the prognosis, regular review, and pay attention to the husband and wife in the treatment. 1. Reasonable use of medication: Inadequate dosage of medication or inappropriate medication program can lead to difficulty in curing the disease. Patients can consult a doctor in time and apply roxithromycin, moxifloxacin, doxycycline and other drugs under the doctor’s guidance for treatment. Only reasonable use of medication can better cure this disease. If it is mycoplasma urealyticum, it can be transmitted through sexual contact, and the treatment should emphasize the husband and wife in the same treatment. 2. Strengthen life management: during the treatment period, you should maintain good personal hygiene, avoid sexual life; strengthen rest, avoid staying up late; moderate exercise, improve the body’s immunity. 3. Regular review: this disease is characterized by easy recurrence, after the treatment, you can also regularly review, in order to facilitate timely adjustment of the medical program. Mycoplasma genitalium infection, such as no symptoms do not need treatment. The patient’s condition is different, the recurrence situation is different, specific how to treat, it is recommended to follow the doctor’s advice.