The duration of bone pain in multiple myeloma cannot be generalized, it can be transient in early stage, and the pain will be prolonged in later stage, which is related to the progression of the disease. Bone pain is often the first symptom of multiple myeloma, and it is also one of the most important symptoms of the disease. Bone pain is not specific, and the degree of severity varies. In the early stage, bone pain is mostly mild, temporary, wandering or intermittent. With the progress of the disease, the bone pain can become persistent, intense, and even pathological fractures. At the beginning of the disease, bone pain mostly appears in the lumbar region, followed by the sternum, ribs and limbs. When the pain is persistent, localized pressure, bulging or fluctuating sensation will appear, and often pathological fracture occurs in non-weight-bearing parts. When symptoms occur, it is recommended that patients go to a regular hospital in time to clarify the cause of the disease, and receive standardized treatment under the guidance of a professional physician, so as to avoid delaying the condition.