The pain in the legs after squatting and standing up, common muscle strain, degenerative osteoarthritis several causes, as follows: a. Muscle strain: such as pain in the thigh muscles and calf muscles, usually due to muscle strain or muscle trauma caused by the patient in the process of squatting up, the muscle will continue to force, such as strain or trauma occurs, will cause local pain symptoms. Second, degenerative osteoarthritis: such as for knee pain or ankle pain, usually degenerative osteoarthritis, the patient in the squat to stand up, stimulating the synovial membrane and joint surface cartilage, thus inducing pain symptoms. Patients usually experience significant leg joint pain when walking up and down stairs and when squatting, along with weakness in the leg muscles. Pathological changes such as cartilage degeneration and synovial hyperplasia are usually easily detected by MRI. With leg muscle strength training and avoidance of local trauma, recurrent symptoms can be prevented.