The knee pain when standing up after squatting and the knee pain when walking can be caused by the following reasons: First, severe osteoarthritis of the knee, severe osteoarthritis of the knee can involve the cartilage, meniscus, and surrounding soft tissues, resulting in damage to these tissues, resulting in obvious pain in the knee joint when walking and standing up after squatting, which should be examined by X-ray and CT of the knee joint for early diagnosis and treatment. Second, patellofemoral osteoarthritis, patellofemoral osteoarthritis of the knee joint when serious, can have squatting after getting up knee pain, walking obvious knee pain symptoms, this time to check the knee joint MRI, X-ray to diagnose and treatment. Third, knee ligament damage, such as knee patellar ligament, quadriceps tendon and goose foot ligament damage, can have squatting and standing up knee pain and pain when walking, then early examination and MRI of the knee joint to early diagnosis and treatment.