Syphilis is serious or HPV (human papillomavirus) infection is serious, can not be generalized, both diseases are a kind of infectious diseases, the specific degree of severity and the stage of development of the disease, the patient’s physique and other factors related to the severity of the disease, when serious, the two diseases will be on the human body’s health to cause adverse effects, there is no comparability between the two. Syphilis is mainly caused by syphilis spirochete infection of sexually transmitted diseases, mostly by sexual contact, mother and child, blood and other modes of transmission, often after regular treatment, most patients with early syphilis have a good prognosis, the prognosis of late syphilis is not ideal, often irreversible multi-organ damage, affecting normal life, and even trigger the death of the patient. HPV infection is a human papillomavirus infectious disease, there are high-risk HPV infection and low-risk HPV infection, usually high-risk HPV16, HPV18 is more serious, can cause cervical cancer, threatening women’s lives. HPV6 and HPV11 are the most serious of the low-risk types, which can cause warts. After active treatment, the prognosis is better, but if left untreated, it is easy to develop into a malignant tumor. It is recommended that patients who are diagnosed with syphilis or HPV infection need to go to a regular hospital in a timely manner, under the guidance of a professional physician reasonable treatment, to avoid delaying the condition.