Urine β2 microglobulin higher than the normal value does not exist in absolute seriousness, but higher than the normal value are suggestive of impaired tubular reabsorption function, which can be seen in a variety of diseases, such as upper urinary tract infection, diabetic nephropathy, hypertensive nephropathy, autoimmune disease renal damage and so on. 1. Upper urinary tract infection in the acute stage can be cured by oral anti-infection treatment, and oral antibiotic drugs such as levofloxacin can be restored to a healthy level without any seriousness as prescribed by the doctor. 2. Diabetic nephropathy, hypertensive nephropathy: need to symptomatic control of the primary disease, control of blood glucose, blood pressure, regular review, to slow down the rate of progression of renal disease, strict compliance with the doctor’s orders can control the development of the disease after treatment. 3. Autoimmune disease renal damage: if the condition permits, the diagnosis of renal pathology can be clarified according to the doctor’s instructions, and hormone or immunosuppressant treatment, such as prednisone or cyclophosphamide and other drugs can be given according to the doctor’s instructions, and the renal damage of autoimmune disease is relatively more serious. If the urine β2 microglobulin is elevated, it is recommended to consult the hospital in time, according to the actual clinical symptoms and other relevant examination results, by the professional physician to determine the cause of elevation, and actively treat the primary disease.