Antidepressants do not have a negative impact on mood and can alleviate the adverse effects of depression, such as: anxiety, nervousness, prolonged low mood with a tendency to depression, sleep disorders and so on, when these symptoms associated with depression are alleviated, the patient’s mood will be much lighter. Antidepressants have selective pentahydroxytryptamine reuptake inhibitors, including: fluvoxamine and citalopram, is the most widely used antidepressant, with oral absorption is easy, high rate of binding to plasma, rapid effect and so on, it is the most widely used antidepressant in clinical practice. Antidepressants also include norepinephrine and dopamine repeat uptake inhibitors, including: nomefensine, bupropion, etc., mainly through the inhibition of norepinephrine and its repeat uptake function, so as to effectively inhibit depression. Patients suffering from depression should immediately seek medical attention, and use medication reasonably under the guidance of a doctor, and must not use medication on their own to avoid delays.