The treatment of methylmalonic acidemia is divided into acute phase treatment and long-term treatment. In the acute phase of the disease, protein and calorie restriction is the main treatment, and dialysis is needed when hyperammonemia occurs. Long-term treatment mainly involves low protein diet and special formula milk, and vitamin B12 and other drugs are supplemented at the same time.
1. Acute treatment: Acute treatment of methylmalonic acidemia should focus on rehydration and acid correction, while limiting protein intake and supplying appropriate calories. If hypoglycemia occurs, intravenous glucose can be given first. If hyperammonemia persists, toxic metabolites need to be removed by peritoneal dialysis or hemodialysis.
2. Long-term treatment: The principle is a low-protein, high-energy diet to reduce the accumulation of toxic metabolites. Special formulas for methylmalonic acidemia or protein powders are used, along with small amounts of natural proteins. Medication includes vitamin B12 and L-carnitine.
There may be other treatments for methylmalonic acidemia, and it is recommended that you visit a hospital promptly for targeted management or treatment. All the above medications should be used under the supervision of a doctor.