I. Objective To analyze the main points of nursing care for severe ovarian hyperstimulation syndrome to discharge ascites by laparotomy, and to provide scientific basis for improving the nursing effect of patients with severe ovarian hyperstimulation syndrome. Methods 50 patients with severe ovarian hyperstimulation syndrome were selected from January 2014 to June 2015 and randomly divided into observation group and control group, 25 cases in each group. All patients were treated with ultrasound-guided peritoneal puncture and ascites release, the control group adopted conventional nursing mode, and the observation group applied nursing intervention mode on the basis of the control group. Observe the nursing effect, hospitalization time and satisfaction with nursing care of the two groups. Most of the patients with severe ovarian hyperstimulation syndrome (OHSS) appeared in controlled superovulation, and some of them appeared in ovulation cycle. The disease is an endocrine abnormality, and clinical treatment is mostly based on the treatment plan of sexual peritoneal puncture and ascites release, which can effectively reduce the dyspnea caused by the increase in intra-abdominal pressure due to the increase in ascites, and help to reduce the rate of complications, improve the quality of life of patients, and ensure the safety of mothers and infants. This paper analyzes the nursing points of ascites release by laparotomy in severe ovarian hyperstimulation syndrome, and is reported as follows. II.METHODS The control group adopted the routine nursing mode, including basic nursing, health education, dietary guidance and other measures. The observation group applies the nursing intervention mode on the basis of the control group, specifically as follows: Psychological care: patients with severe ovarian hyperstimulation syndrome have a sudden onset, clinical symptoms are more serious, and the patients may have negative emotions such as anxiety and depression after being affected. Responsible nurses should promptly introduce the disease with the patients, provide comprehensive answers to the questions raised by the patients, and provide psychological counseling on the psychological state of the patients, as well as introduce the medical level of our hospital, the importance and feasibility of the treatment program. Basic nursing care: make room rounds once/h, record the patient’s heart rate, respiration, blood pressure and other indicators, observe whether the patient has symptoms such as shortness of breath, respiratory disorders, nausea, vomiting, etc. Record the patient’s food intake and excretion, body weight, chest circumference and other indicators every day, and do it at regular intervals and in a certain amount to avoid recording errors. Nursing care before puncture: maintain the environment of the treatment room, do a good job of sterile disinfection measures, control the light, temperature and humidity in the appropriate range, if necessary, can prepare the screen. Prepare the ultrasound machine, blood transfusion machine, suture removal kit, sterilized gloves and other instruments and medical supplies needed in the treatment. Puncture cooperation: help the patient to adjust to the flat, semi-recumbent or slightly left lateral position, in the ultrasound-guided puncture positioning, select the more obvious parts of the effusion, puncture point according to the patient’s actual situation, routine disinfection of the puncture site, spreading the towel, the use of 12-gauge venous needle puncture, back to the infusion of ascites can be seen in the abdominal cavity will be sent to the needle again 3mm, the core of the needle will be pushed out, you can begin to put ascites, vital signs are stable! Patients can put ascites >3000mL at one time. Nutritional support: after the end of the treatment, patients will feel symptomatic relief, appetite improvement, because of the importance of dietary supplementation of energy as well as protein, it is recommended that the patients eat small meals, pay attention to vitamin supplementation. III.DISCUSSION Ovarian hyperstimulation syndrome is one of the major complications of modern assisted reproduction techniques, mainly due to the stimulation reaction caused by ovulation stimulating drugs, which is characterized by the development of multiple follicles in the bilateral ovaries, ovarian anomalies, increased capillary permeability, increased secretion of body fluids as well as increased protein extravasation. Peritoneal puncture and ascites release is an effective treatment for ovarian hyperstimulation syndrome, but patients’ tolerance of it is low, mainly because of the concern that this treatment measure may have a certain effect on the effectiveness of the application of artificially assisted procreation techniques or on the fetus. Effective nursing interventions can significantly improve the clinical efficacy of patients, alleviate clinical symptoms, and improve the prognosis of patients. The results of this study showed that the observation group was significantly better than the control group in all aspects, indicating that providing patients with symptomatic nursing interventions, strengthening psychological care, reinforcing the preparations for laparotomy, emphasizing the monitoring of vital signs during ascites release, cooperating with the physician’s operations, and providing good dietary guidance after ascites release can guarantee the clinical efficacy of the patients, which is worthy of being promoted for use in clinical practice.