Difficulty in breathing when sleeping flat on your back may be caused by rhinitis, cold, pneumonia, heart disease and other diseases, which can be treated with general treatment and medication. 1. Rhinitis: patients may manifest nasal congestion, sneezing, and may also have difficulty in breathing when sleeping flat, etc. Hot towels can be used to compress the nose. Nasal sprays containing budesonide and mometasone furoate can also be used locally to reduce the inflammatory reaction of the nasal mucosa and relieve the above symptoms. Oral anti-allergy drugs, such as loratadine, cetirizine, etc. can also be taken. 2. Colds: when the symptoms of nasal congestion are severe, the symptoms of dyspnea may also appear when sleeping and lying down, and decongestants (pseudoephedrine) can be used to reduce the symptoms of nasal congestion and relieve dyspnea. 3. Pneumonia: generally patients show cough, cough sputum, when the symptoms are serious, may also be manifested as sleep when lying down dyspnea, need to actively seek medical attention, clear infection, need to actively anti-infective treatment, at the same time can be used to diastolic bronchial drugs, such as aminophylline, etc., and at the same time, can be given to the nasal catheter or mask oxygen, to keep the airway open. 4. Cardiovascular disease: such as acute left heart failure, patients may manifest cough, cough sputum, dyspnea when lying down. Need to take the sitting position, legs down, can use theophylline, diuretics (furosemide), digoxin and other drugs for treatment. Difficulty in breathing while lying down may be due to other diseases, and if the symptoms are severe, it is recommended to go to the hospital. The above medications are recommended to be used under medical supervision.