Whether it is better to take one injection of 60 micrograms or three injections of hepatitis B vaccine for adults needs to be chosen according to one’s own situation, and there is no clear distinction between good and bad. Three shots of adult hepatitis B vaccine refers to 10 micrograms or 20 micrograms of hepatitis B vaccine, the main vaccination program for 0, 1, 6 months vaccination, the possibility of producing antibodies after the first shot of hepatitis B vaccine is about 40%, the possibility of producing antibodies after the second shot is about 80%, the possibility of producing antibodies after the three shots of vaccination is about 90%. Hepatitis B vaccine of 60 micrograms contains relatively large amount of hepatitis B surface antigen, which leads to enhanced immune response after injection into the body, so the production of antibodies is relatively rapid, and the titer is relatively high, but it may also cause side effects, such as fever, redness and swelling at the site of inoculation. Through three injections of 10 micrograms or 20 micrograms of hepatitis B vaccine, most people will produce surface antibodies against hepatitis B. People who do not produce surface antibodies after vaccination can be strengthened with one injection of 60 micrograms of hepatitis B vaccine. For hepatitis B vaccination, it is recommended to consult the community health center for vaccination.