Vague pain on one side within the perianal area may be due to hemorrhoids, rectal polyps, infections, perianal abscesses, tumors and other diseases. 1. Hemorrhoids: Obstruction of venous return caused by poor circulation around the gate may result in the formation of venous masses, causing hemorrhoids, which may lead to vague pain on one side of the perianal area. 2. Rectal polyps: rectal polyps due to localized friction or extrusion, may also cause vague pain in the perianal side of the symptoms. 3. Infection: such as proctitis, anal canal inflammation, anal sinusitis, etc., can also cause the phenomenon of perianal pain on one side. 4. Perianal abscess: purulent infection of the soft tissues around the anus can also lead to the phenomenon of perianal pain on the other side. 5. Tumor: such as rectal cancer, anal cancer and other malignant tumors, may also be manifested as vague pain in one side of perianal area. There may be other reasons for the vague pain in one side of perianal area, so you need to go to the hospital for examination in time and follow the doctor’s instruction.