Gallstones are caused by changes in the ratio of bile acids and cholesterol in the gallbladder. Oral medications mainly include antispasmodic and analgesic drugs and anti-infective drugs. 1. Antispasmodic and analgesic drugs: gallstones can cause biliary colic and spasm of the smooth muscles of the bile ducts if they form a jam. Antispasmodic and analgesic drugs have the effect of anti-M choline receptors or blocking M receptors, which can relieve the spasm of bile duct smooth muscle and reduce the symptoms of biliary colic. Commonly used drugs include atropine tablets, scopolamine tablets and so on. 2. Anti-infective drugs: most of the patients with gallstones have biliary tract infections, which can be treated with oral antibiotics such as cephalosporins and penicillins, such as cefoperazone and amoxicillin, etc. The above drugs should be used under the supervision of a doctor. All of the above medications should be used under the guidance of a doctor to avoid self-medication.