Definition: Fibromyalgia syndrome is a group of clinical syndromes of unknown etiology characterized by widespread generalized pain and marked somatic discomfort, often accompanied by fatigue, sleep disturbance, morning stiffness and psychiatric symptoms such as depression and anxiety. It can be divided into primary and secondary. ACR-1990 diagnostic criteria: 1. generalized pain lasting for more than 3 months 2. pressure pain in at least 11 of the 18 pressure points of the body. ACR-2010 diagnostic criteria: 1. Diffuse pain index >7 and symptom severity score >5 or WPI=3-6 and SS score >9; 2. Symptoms persist at the same level for more than 3 months; 3. Patients do not have explainable pain from other diseases. Important changes in the new diagnostic criteria for FMS: 1. The number of pressure points is not emphasized; 2. The number of pain sites is improved in the diagnosis; 3. WPI and SS scores can be applied to quantify pain and symptom severity. FMS is more common clinically, prevalent in women, mostly in people aged 20-70 years, and the disease has a high incidence, second only to osteoarthritis. Clinically, FMS is easily and often misdiagnosed as spondyloarthritis, osteoarthritis, osteoporosis, and postpartum rheumatism, and many are missed. Treatment of FMS: Once a clear diagnosis is made, the key to treatment is to make patients understand their disease and to convince them that their disease can be effectively treated but will not deteriorate, let alone be crippling or fatal. Be sure to build up the confidence that you can overcome the disease. Pay attention to exercise to make yourself more energetic! Secondly, you can take oral non-steroidal anti-inflammatory analgesics, antidepressants.