Muscle fiber tremor is a stimulation phenomenon of the anterior horn cells of the spinal cord or the motor nucleus of the cranial nerve, and is a small, rapid or peristaltic-like tremor within a few centimeters of the muscle belly of a muscle. It is a continuous fluctuating undulation of the muscle group, caused by continuous spontaneous contraction of the motor unit. Amyotrophic lateral sclerosis causes tremors in muscle fibers, and amyotrophic lateral sclerosis (ALS), commonly known as acromegaly, can involve either upper motor neurons (brain, brainstem, spinal cord) or lower motor neurons (cranial nuclei, anterior horn cells of the spinal cord). It is also called motor neuron disease (MND), or Charcot’s disease in France and Lou Gehrig’s disease in the United States. In China, amyotrophic lateral sclerosis and motor neuron disease are usually used together. It is characterized by peripheral paralysis of the upper extremities, central paralysis of the lower extremities, and mixed, symmetrical damage to upper and lower motor neurons. The exact pathogenesis is still unclear. Recent studies have focused on the copper-zinc superoxide dismutase gene mutation theory excitatory amino acid toxicity theory, autoimmune theory and neurotrophic factor theory. 1, copper and zinc superoxide dismutase gene mutation theory Research shows that 20% of familial ALS have SODI (Cu/Zn peroxide dismutase) gene mutation. This gene is located on human chromosome 21q22.1, and its mutation can lead to loss of SODl activity and weaken the detoxification effect of superoxide, resulting in excessive accumulation of free radicals and cellular damage. Some sporadic ALS may also have mutations in the 2lq22 locus. 2. Excitatory amino acid toxicity theory Excitatory amino acids include glutamate aspartate and its derivatives erythropoietic acid (KA), quercetin (QA), gooseberry acid (IA) and N-methyl d-aspartate (NMDA). Excitotoxicity of excitatory amino acids may be involved in the pathogenesis of LIS glutamate binding to NMDA receptors leads to calcium in-flow activation of a series of proteases and protein kinases, resulting in increased protein catabolism and free radical production, enhanced lipid peroxidation processes, and neuronal autolysis In addition, excess calcium activates nuclear endonucleases, leading to DNA cleavage and nuclear disintegration The lesions of ALS are mainly confined to the motor nervous system and may The lesions in ALS are mainly confined to the motor nervous system and are probably related to the glutamate uptake system. This uptake system is located in the cell membrane of glial cells and nerve cells and rapidly transports glutamate from the synaptic gap into the cell to terminate its action. Animal studies have also shown that intrathecal injection of KA and NMDA in mice can cause degeneration of spinal cord neurons.