High percentages of naïve granulocytes are usually a sign of two major systemic diseases: 1. The most common diseases are hematologic diseases, such as leukemia and myelodysplastic syndrome, which can lead to an increase in the percentage of naïve granulocytes in the blood. 2. The high percentage of granulocytes can be caused by bacterial or other pathogenic microorganisms such as mycoplasma, chlamydia or even fungal infections. 3. Patients with very low immunity may also have high percentage of granulocytes due to poor immunity, such as tumor patients and AIDS patients.