Hemolytic occult blood and non-hemolytic occult blood can be caused by diseases, if not standardized treatment, both have obvious effects on health, can not compare which is more serious. 1. Hemolytic occult blood: hemolytic occult blood has more causes, more obvious clinical manifestations and worse prognosis. It includes intravascular hemolysis and extravascular hemolysis. Intravascular hemolysis includes blood group incompatibility transfusion, serosanguineous disease, paroxysmal sleep hemoglobinuria, and so on. Extravascular hemolysis includes hereditary spherocytosis, thalassemia and so on. 2. Non-hemolytic occult blood: urine and fecal specimens contain intact red blood cells, indicating that red blood cells are not caused by fragmentation in the body, which can exclude the anemia caused by hypersplenism, red blood cell abnormality and blood group incompatibility. It is mostly seen in nephritis and urinary stones. It is recommended that patients found with occult blood should be further examined to determine whether the red blood cells are intact and whether hemolysis exists. If hemolysis is present, the cause should be further searched for and professional treatment should be taken.