Duodenal bulb ulcer should be given medication in the form of relief, and surgery can be performed if necessary. 1. Pharmacological treatment: It is recommended to take proton pump inhibitors, gastric mucosal protectants and other drugs under the guidance of doctors, such as omeprazole, bismuth potassium citrate, etc. Such drugs have allergic and other adverse reactions, and should not be used blindly on their own. Patients with combined Helicobacter pylori infection undergo eradication therapy, often using quadruple therapy, such as omeprazole, bismuth potassium citrate, amoxicillin and clarithromycin. It is also necessary to improve dietary habits, such as eating regularly, avoiding overeating, and not consuming spicy, stimulating and hard foods. 2. Surgical treatment: duodenal bulbous ulcer combined with bleeding, perforation, organic pyloric obstruction that is ineffective in medical treatment, and there is no contraindication to surgery, surgical treatment needs to be given to alleviate the situation, so as not to jeopardize the life of the patient. Duodenal bulbous ulcer should be standardized treatment under the guidance of a doctor to avoid delay.