Thermoregulatory disorders refer to fever caused by abnormalities in the thermoregulatory center due to central nervous system disorders. Thermoregulatory disorders are relatively rare among the various causes of fever, and their performance and disposition are different from those of the common infectious and other causes of fever. Therefore, when determining central fever, infectious, drug-induced and other causes of fever should be excluded first. For difficult to explain the moderate temperature increase can not be easily considered as central fever. It is commonly associated with hypothermia, phenothiazine antipsychotic intoxication, craniopharyngioma, anxiety disorders, and hypothalamic disorders. Dysfunction of the central nervous system affects the function of the vegetative nervous system and causes abnormal function of the cardiovascular system The etiology of the disease may be related to physical, neurological, peripheral environment, and genetic factors. Some patients are often in a state of depression and anxiety and sadness are also more likely to cause thermoregulatory disorders. It is mainly due to the dysfunction of the central nervous system, which affects the function of the vegetative nerve and causes abnormal function of the cardiovascular system. The etiology may be related to physical, neurological, behavioral, peripheral environment, and genetic factors. The patient’s neurological type is often weak, more depressed and anxious, and when mentally stimulated or working under stress, he or she often fails to adapt to the environment and is prone to develop or aggravate his or her symptoms. Mental and environmental stimuli can cause various physiological changes, mainly manifested as increased sympathetic nerve activity and increased secretion of glucocorticoids. Clinical studies have also shown that patients with this disease have abnormal responses to exercise, psychological tests and painful stimuli, such as lower maximum oxygen consumption during exercise than normal and decreased arterial and venous oxygen content, as well as slowed capillary blood flow and increased blood lactate. Hypothermia Hypothermia can be caused by prolonged exposure to any temperature where the body’s heat loss is greater than its heat production. Hypothermia most commonly occurs in the cold season or when immersed in water, but can also occur in the summer or warm season if metabolic or active heat production (shivering) does not maintain core body temperature. Hypothermia can also occur after severe trauma. Immobilization, wet clothing, cold winds and lying on cold surfaces can increase the risk of hypothermia. Anxiety Disorders Anxiety disorders, also known as anxiety neuroses, are characterized by generalized anxiety disorder (chronic anxiety disorder) and episodic panic states (acute anxiety disorder), often accompanied by dizziness, chest tightness, palpitations, dyspnea, dry mouth, urinary frequency, urgency, sweating, tremor, and motor restlessness, and are often accompanied by dizziness, chest tightness, palpitations, difficulty in breathing, dry mouth, frequent urination, urgency, sweating, tremor, and motor restlessness, and by anxiety that is not induced by an actual threat or a degree of nervousness and alarm that is very much disproportionate to the reality of the situation.