In stroke prevention, there is a positive correlation between blood pressure reduction and endpoint events, but not a lower one. The “J” curve phenomenon, in which the incidence of major cardiovascular and cerebrovascular disease decreases when blood pressure decreases to a specific level, but continues to decrease blood pressure, the incidence of cardiovascular and cerebrovascular events increases. When blood pressure is around 130-139/80-85 mmHg, the incidence of cardiovascular events is lower, which provides evidence for determining the ideal blood pressure lowering target. To lower blood pressure to the target, it is sometimes necessary to combine several antihypertensive drug treatments.