It is recommended to go to the hospital for examination to clarify the cause of the disease and then deal with it symptomatically. First, penile pearl-like papules, it is often distributed in the glans coronalis area, accompanied by papilla-like or granuloma-like protrusions. Painless, smooth surface, no bleeding, secretions, bad odor, and no infection, no change in volume, size, or number, and can exist for a long time. This situation may be related to circumcision or circumcision, etc., without any treatment, such as excessive concern, can be electrocautery treatment. The second is a sexually transmitted disease, mostly through impure sexual contact transmission, can be manifested on the genital papilla-like, or cauliflower-like sarcoma, volume, size, number can be increased over time, fusion and other changes. Focal excision is recommended or, if necessary, along with excision of the foreskin if the number is excessive. After surgery, the pathological diagnosis is clear, it is recommended to give antiviral medication, which can be chosen from interferon alpha 2b 3 million IU intramuscular injection, once every other day, for half a month.