Left clavicular lymph node metastasis of pancreatic cancer suggests that the cancer has entered into advanced stage, with poor prognosis, and the survival period is generally within 1 year, so it is recommended to improve the prognosis of the disease through active treatment, and to improve the quality of life through palliative surgery and so on if necessary. When left clavicular lymph node metastasis occurs in pancreatic cancer, radiotherapy or targeted therapy can be used to inhibit the malignant proliferation of the tumor, shrink the tumor foci, alleviate the pain of the patient, improve the quality of life of the patient, and prolong the survival time of the patient. Chemotherapy drugs include cyclophosphamide, cytarabine, vincristine, cisplatin, paclitaxel and so on; targeted drugs include everolimus, sunitinib, erlotinib and so on. Due to individual differences, the drugs are recommended to be used under the guidance of a doctor, and it is recommended to seek medical treatment after the occurrence of adverse reactions, and the use of drugs is prohibited for those who are allergic to the drugs. In advanced pancreatic cancer, distant lymphatic metastasis has already appeared, and often the chance of radical treatment has been lost. At this time, due to the blockage of the pancreatic duct, jaundice and pancreatitis are easy to appear, and palliative surgery can be chosen to improve the quality of life.