Retinal vein occlusion (RVO), which is divided into central vein occlusion (CRVO) and branch vein occlusion (BRVO), is a group of diseases that cause severe visual impairment. In recent years, retinal vascular diseases have attracted great attention due to some traditional risk factors, such as hypertension, diabetes, and smoking. And none of these risk factors are sufficient to explain the development of stroke. Retinal vascularity is unique in that the fundus vessels can be seen directly through non-invasive indirect fundoscopy. RVO has been reported to be a risk factor for stroke. However, there are mixed findings regarding the relationship between RVO and stroke. To assess the risk of developing stroke after retinal vein occlusion, Dr. Rim et al. conducted a 9-year study, the results of which were published in Ophthalmology on January 8, 2015, which concluded that retinal vein occlusion is highly associated with stroke occurrence. The study collected relevant data from the Korean National Health Insurance Research Database, and data from 1025,340 randomly selected Korean residents out of 4660,5433 residents in 2002 were analyzed. Patients diagnosed with RVO or stroke in 2002 were excluded, and the RVO group included patients with first diagnosis of CRVO or BRVO from January 2003 to December 2005 (344 patients in 2003, 375 patients in 2004, and 312 patients in 2005). Patients in the control group were randomly selected (1 in 5 diagnosed with RVO; 1696 patients in 2003, 1854 patients in 2004, and 1524 patients in 2005) and matched to the RVO group based on age, sex, area of residence, household income, and year of diagnosis of RVO, and patients were followed up until 2010. After adjusting for potential confounders such as hypertension, diabetes mellitus, and chronic kidney disease, Cox proportional risk regression was used to calculate the overall survival rate for stroke development. The results showed that 16.8% of patients in the RVO group had stroke progression compared with 10.7% in the control group, suggesting that retinal vein occlusion may increase the risk of stroke development. Hypertension, diabetes and chronic kidney disease can also increase the risk of stroke. RVO increases the risk of ischemic stroke and hemorrhagic stroke. In terms of age, the risk of hemorrhagic stroke is higher in younger RVO patients. Younger patients were defined in the study as <50 50="" 69="">69 years old. Studies have shown that retinal vein occlusion is highly associated with stroke development. And RVO increases the risk of both ischemic stroke and hemorrhagic stroke. Notably, the risk of hemorrhagic stroke is two times higher in young RVO patients than in older patients. Therefore, for ophthalmologists, they should be alert to the development of stroke in patients with RVO, especially in younger RVO patients.