The most common tissue type of bladder cancer is uroepithelial carcinoma. Bladder cancer is one of the most common malignancies in urology. Bladder cancer encompasses uroepithelial, squamous cell, and adenocarcinoma, followed by the less common small cell, mixed, carcinosarcoma, and metastatic cancers. Among them, uroepithelial carcinoma is the most common, accounting for more than 90% of bladder cancers. Squamous carcinoma accounts for about 5%, and adenocarcinoma of the bladder is even rarer. The 2016 edition of WHO bladder tumors contains invasive uroepithelial carcinoma with multidirectional differentiation, nested subtypes including large nests, microcystic, micropapillary, lymphoepithelioma-like, plasma cell-like/imprinted cell-like/diffuse, sarcomatoid, giant cell-type, poorly differentiated, lipid-rich, clear-cell-type, mullerian-type tumors, and tumors originating from bladder diverticula. In conclusion, the most common pathologic type of bladder cancer is uroepithelial carcinoma. If bladder cancer is suspected or diagnosed, it is recommended to go to regular hospitals for comprehensive assessment of the condition, follow the doctor’s instructions to cooperate with the treatment, and choose the appropriate treatment plan to avoid delaying the condition.