Sperm are the reliable helpers of human reproduction. If the testes are compared to the “factory” where sperm are made, the varicocele in the testes is the “workshop” where sperm are made – sperm are born here. Sperm are born here. The sperm matures in the epididymis, the “warehouse”, and gains the ability to move and fertilize. At the end of the vas deferens, the sperm glands secrete seminal fluid that mixes with the sperm, just like packaging the sperm, and the “finished product” is finally discharged into the urethra through the ejaculatory ducts to complete their mission. Imagine that a factory is not able to produce the product and deliver it to the designated location, there are only two parts that go wrong, the “machine” and the “transport channel”. Now, we can compare the human testicles to the “machine” and the vas deferens to the “transport channel”. The so-called azoospermia refers to three consecutive sperm retrievals, the ejaculated semen is centrifuged and precipitated, and no sperm is found after microscopic examination. Azoospermia is not rare and accounts for about 1% to 2% of the population of fertile men, which means that about one in 50 to 100 men may have azoospermia. At least 30 million men worldwide have been diagnosed as azoospermic. Currently, treatment can be divided into two main categories according to the specific circumstances of the azoospermia patient: Category 1: For patients with pseudospermia, the blocked vas deferens can be improved by medication or surgery. If the results are not good, testicular or epididymal puncture can be attempted to retrieve sperm and after obtaining sperm, you can obtain your own child through second generation IVF assisted conception, also known as oocyte plasma single sperm microinjection. This method is simple and easy to use, and the current IVF technology is mature and has a high pregnancy rate for assisted conception. Category 2: For patients with true azoospermia, it is generally difficult to improve through surgery or medication, and most of these patients often give up because they are untreatable, or become sterile for life or adopt other children or seek fertility with the help of sperm from human sperm banks. However, not all patients with true azoospermia are willing to undergo donor sperm treatment and may try testicular microsperm retrieval therapy. Studies have shown that even in patients with severe spermatogenesis, some spermatogenic tissues may remain in the testes, but these tissues are so rare that they are difficult to locate by traditional testicular puncture methods. With the help of a surgical microscope, the probability of finding these tissues increases by about 35%, just as it is possible to find an oasis in the desert. The probability of finding spermatozoa is not reduced by small testicular size, significantly elevated FSH, or chromosomal abnormalities, and the probability of finding spermatozoa in a testicle as small as 2 mL (only about the size of a peanut meter) is the same as in a testicle of normal size. So, even if you are judged to be azoospermic, don’t be frustrated, actively cooperate with the examination, according to the actual situation for treatment, there is still a great hope to have your own baby!