Pain at the junction of the lower back and buttocks may be due to ankylosing spondylitis and lumbar disc herniation problems. 1. Ankylosing spondylitis: usually refers to the chronic progressive inflammation that invades the spine and involves the sacroiliac joints and the surrounding joints, and manifests itself as low back pain, morning stiffness, spinal ankylosis, spinal deformity and other symptoms, which can be treated with drugs such as celecoxib, etanercept, and salicylazosulfapyridine. 2. Lumbar disc herniation: usually due to disc degeneration, rupture of the annulus fibrosus and herniation of the nucleus pulposus, manifesting as low back pain, sciatica, radiating pain in the lower limbs, scoliosis and reduced mobility of the lumbar spine, etc. It can be treated with drugs such as ibuprofen delayed-release capsule, meloxicam and cloxacillin. The cause of the pain at the junction of the lumbar and hip area should be determined first, and in general, it can be improved by medication, but in serious cases, it is necessary to go to the hospital in time and follow the doctor’s advice for treatment. The above drugs should be used under the guidance of a doctor, avoid self-medication.