Hepatitis B 45 positive is a sign of having been infected with hepatitis B and usually does not turn negative. Hepatitis B 5 tests 45 positive, that is, hepatitis B core antigen and hepatitis B core antibody are positive, indicating that there has been previous infection with hepatitis B virus, but due to the body’s strong resistance, the virus has been cleared from the body; or it may be the recovery period of acute HBV infection. A 45-positive hepatitis B 5 test generally has no adverse effects on the human body. Having been infected with the hepatitis B virus, hepatitis B core antibodies often persist for many years, requiring regular retesting of the hepatitis B 5 test, which usually does not turn negative and does not require special treatment. If you find abnormal hepatitis B 5 test, you can consult the Department of Infectious Diseases or the Department of Gastroenterology in regular hospitals for diagnosis and treatment.