The price of domestic Hepatitis B vaccine ranges from 20 to 300 yuan per injection, and the exact price is mainly affected by the specifications of the drug, the drug manufacturer and the medical institution. The current main specifications of domestic hepatitis B vaccine include 10 micrograms, 20 micrograms and 60 micrograms, with the price of 10 micrograms at about 20 yuan per shot, 20 micrograms at about 40 yuan per shot and 60 micrograms at 260~300 yuan per shot; the price varies among different drug manufacturers, and there are also slight differences in pricing among different medical institutions, with most of them costing no more than 300 yuan. Indications: mainly used for hepatitis B vaccination. Adverse reactions: chills, headache, fever, nausea, vomiting, rash, and abnormalities of liver and kidney function may occur after use of the drug. Contraindications: Injection is prohibited for people with severe acute or chronic diseases; injection is prohibited for pregnant women; injection is prohibited for people with uncontrolled epilepsy or other neurological disorders; injection is prohibited for people who are allergic to the product or related immunoglobulins. If obvious gastrointestinal reactions and systemic allergic symptoms occur during injection, it is necessary to consult a doctor for observation and standardized treatment under the guidance of clinicians.