Hereditary spastic paraplegia is usually difficult to cure, patients can improve their symptoms and quality of life through medication, physical therapy and rehabilitation. 1. Medication: Hereditary spastic paraplegia can be treated with medication under doctor’s guidance, commonly used medications include baclofen, epirubicin, botulinum toxin, etc., which can reduce the degree of stiffness of paraplegic area and improve mobility. 2. Physiotherapy: Patients with this disease can also undergo physiotherapy through hot compresses, massage, acupuncture, baking electricity, etc., to improve muscle strength, reduce muscle atrophy and alleviate the condition. 3. Rehabilitation therapy: patients can also go to the regular hospital in the rehabilitation department under the guidance of physicians to carry out rehabilitation exercises, which can help maintain joint mobility and improve the condition. It is recommended that patients strictly follow the doctor’s instructions to use medication, actively cooperate with the doctor’s treatment, pay attention to monitoring the condition in life, if the condition worsens, it is necessary to consult a doctor in a timely manner.