Blake’s cyst is a congenital developmental abnormality in children’s craniosynostosis. It grows mainly in the posterior cranial fossa of the brain, where it forms as a cyst of embryonic remnant tissue due to certain abnormalities in the development of the neural tube. Blake’s cyst is essentially cerebrospinal fluid encased within membranous tissue. The effect on the human body is mainly due to gradual growth, which may compress the brain tissue, resulting in a series of clinical symptoms that lead to abnormal brain function. The lesion is generally common in infants and young children, and many of them will cause increased head circumference, epileptic convulsions, growth retardation and other corresponding manifestations, which are usually diagnosed through CT or MRI examinations. Surgical intervention, such as a third ventriculostomy, may be considered if obstructive hydrocephalus is present or if the child’s life is seriously jeopardized. In the vast majority of cases, the clinical prognosis is very good, and it makes sense to be proactive with the relevant investigations and treatments.