The phenomenon of puffy hands and face in the morning may be the following problems: 1, kidney disease: renal hypoplasia, reduced excretion can lead to sodium retention and cause edema, mostly face and eyelid edema is common, can be carried out to clarify the condition of the renal function and urinalysis; 2, liver disease: insufficient synthesis of protein by the liver, resulting in hypoproteinemia, the colloid pressure in the blood decreases, so that the tissue interstitial water increases The edema is caused by ascites, which is common, and liver function abdominal ultrasound can be performed to make a clear diagnosis; 3. Hypothyroidism: the mucous edema can be detected by thyroid function test to make a clear diagnosis; 4. Central venous stenosis: when the superior vena cava is stenosed, the blood flow of upper limb veins in the head and face can be poor, and the pressure of veins can be elevated, which leads to head and face edema, blood ultrasound and vascular ultrasound can be performed to make a clear diagnosis. Blood ultrasound and vascular ultrasound can be performed to confirm the diagnosis. To sum up, when there is edema of hands, eyelids and face, you should go to regular hospitals in time for relevant examination and timely treatment, so as not to miss the optimal treatment period and cause more damage to the organism.