It is well known that “time is brain!” In the ultra-early stage of acute ischemic stroke onset (within 4.5 hours), pharmacological intravenous thrombolysis can be used to reduce the mortality and disability of stroke in eligible patients. It has been previously suggested that pharmacological thrombolysis with rt-PA within 4.5 hours in eligible patients with acute cerebral infarction increases the rate of revascularization and minimizes patient mortality and disability. One-third of patients can benefit from acute thrombolytic therapy. Since the author started thrombolytic therapy in 2002, he has found that many patients, especially those with cardiogenic embolism and large vessel occlusion, have difficulty in achieving good results from thrombolysis, and large domestic and foreign studies in the past year have confirmed that endovascular treatment of ultra-early cerebral infarction can bring new life and hope to such patients. The Cerebrovascular Disease Center of Deji Hospital is one of the few treatment centers in China that can carry out ultra-early thrombolysis and endovascular treatment for cerebral infarction at the same time. 1.What is thrombolytic therapy? Thrombolytic therapy usually refers to the injection of thrombolytic drugs through veins or arteries in the ultra-early stage (3 hours-4.5 hours) after the formation of cerebral artery thrombus to “melt” the thrombus, restore blood flow to the blood vessels blocked by the thrombus, improve cerebral blood supply, and reduce or avoid serious cerebral infarction. 2.What drugs are available for thrombolytic therapy? At present, the commonly used thrombolytic drugs in China are r-tPA (recombinant tissue-type fibrinogen activator), with the trade name of Aitongli. 3.What is endovascular treatment for acute ischemic stroke? Endovascular therapy is an interventional technique (catheter, microcatheter, stent, etc.) to reopen the lesioned blood vessel by applying thrombolytic drug (Aitongli) or embolizer at the lesioned blood vessel that causes cerebral infarction, thus restoring blood supply to the brain tissue and promoting the recovery of neurological function.