As the role of aspirin in the treatment and prevention of cerebral infarction is increasingly recognized by more and more patients, there has been a marked increase in the number of patients who are consciously taking it on a long-term basis, but there are still very few patients who are taking statin medications. This is related to the fact that physicians are not educated enough about this and patients are misinformed. In recent years, evidence-based medicine has demonstrated that more than 80% of ischemic strokes are related to atherosclerosis, and that plaque instability is a key factor in the occurrence and recurrence of stroke. Numerous studies have demonstrated the ability of atorvastatin to stabilize or reverse plaque through multiple pathways, including LDL reduction, anti-inflammatory, and antioxidant effects. 2009 Meta-analysis of statin therapy showed that statin therapy significantly reduces the risk of stroke, both in primary and secondary prevention, and that the cardiovascular benefits of long-term, intensive statin therapy are even greater. A Greek study with a 10-year follow-up showed significant benefit of long-term statin therapy after discharge from the hospital in patients with first-ever stroke, and statin therapy was an independent predictor of stroke recurrence. A subgroup analysis of liver function in the GREACE study, an exploratory analysis of the liver safety of statins in the Lancet in 2010, showed no impairment of liver function in patients randomized to atorvastatin 10-80 mg (mean 24 mg/day) or conventional therapy with a mean follow-up of 3 years. A concurrent review in the Lancet noted that no monitoring of liver function is required for prescription statins. Regarding the side effects of statin therapy in a large number of clinical studies and practice has proved that the overall safety of statin is favorable. It is recommended that long-term and standardized intensive statin therapy is necessary for a wide range of patients, especially high-risk patients with hypertension and diabetes.