Fever of 38.5 degrees after leprosy vaccination in 8-month-old babies is mostly seen in vaccine reaction, but also seen in toddler’s emergency rash, Kawasaki disease, etc. Intervention needs to be carried out according to the cause, such as considering vaccine reaction needs to be reasonably antipyretic, and dynamic observation and so on. 1. Vaccine reaction: for 8-month-old babies, the above symptoms can appear after vaccination against leprosy, for such children, the general mental response can be, without obvious other abnormal symptoms, the treatment can be used in the form of warm water wipes and other ways to reasonably reduce the fever, if the fever does not go down significantly, but also comply with the doctor’s advice to take ibuprofen and other drugs to reduce the fever, and dynamic monitoring of the body temperature, observation of the mental condition. 2. Pathology (1) Early childhood acute rash: the above phenomenon may occur, some babies may present high fever, often fever 3~5 days fever out of the rash, treatment can be oral antiviral combination of the four seasons treatment, the course of the disease can be followed by the use of ibuprofen, such as reasonable antipyretic. (2) Kawasaki Disease: Fever may appear, temperature is recurrent, often accompanied by chapped lips and mouth, rash and hard swelling of the hands and feet and other symptoms, diagnosis is clear and need to use gammaglobulin and other drug treatment. 8 months baby fever after leprosy vaccine 38.5 degrees, there may be other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, give targeted treatment or treatment.