Pressure pain below the rib cage is most commonly associated with costochondritis or intercostal neuralgia, especially in female patients, and occurs in the 2nd-4th ribs of the anterior chest. It is a self-limiting disease, probably related to autoimmunity, and can be properly exercised. If there are significant symptoms of pain, oral pain medications, including the application of some non-steroidal anti-inflammatory drugs, can be considered. At the same time of treatment, because drugs have relative side effects and tend to irritate the stomach, they can be taken after eating or oral drugs to protect the mucosa of the gastrointestinal tract. Local closure therapy, including injection of lidocaine or local dilution of dexamethasone, is also available and usually provides some degree of relief. Local physiotherapy, including massage, baking, and hot compresses, can also be performed and reviewed regularly. Many patients’ symptoms can gradually return to normal with proper physical exercise and strengthening of the body. In severe cases, CT chest examination can be performed to exclude organic lesions.