Hypothyroidism causing thyroid nodules is generally defined as thyroid nodules with hypothyroidism. In hypothyroidism with thyroid nodules, thyroid nodules can get better with hormone replacement therapy or surgery. The following treatments are available for treating hypothyroidism with thyroid nodules. First, patients can be treated with hormone replacement therapy with levothyroid hormone if the thyroid nodules are not at risk for malignancy after evaluation by a clinician and do not cause pressure symptoms such as difficulty breathing or swallowing. Exogenous thyroid hormone supplements the body’s production of insufficient thyroid hormone for the purpose of treating hypothyroidism, and also inhibits overgrowth of the thyroid gland and reduces the extent of goiter. Secondly, if the nodule produces oppressive symptoms such as difficulty in breathing and swallowing for the patient, which has a greater impact on daily life, or if the nodule is malignant or at risk of malignant transformation after evaluation and diagnosis by the clinician, then surgical treatment is required. In daily life, if you suffer from hypothyroidism with thyroid nodules, please go to a regular medical institution first and follow the doctor’s instructions for reasonable medication.