Serum protein electrophoresis is the determination of the percentage of various types of proteins in the serum to the total protein by electrophoresis, which is meaningful for the diagnosis of liver and kidney diseases and multiple myeloma myeloma is presenting a specific pattern, mostly a spike in the gamma globulin area called m protein, kidney disease has a specific electrophoretic pattern, globulin can be increased, sometimes combined with mild elevation of gamma globulin, liver disease in acute liver necrosis, albumin In acute liver necrosis, albumin decreases significantly and globulin increases significantly. In patients with infectious hepatitis, serum albumin is mildly decreased, there is an increase in gamma globulin, and in severe infections, an increase in alpha1 globulin, hypogammaglobulinaemia and gamma globulin-free anaemia, and an extreme decrease in serum gamma globulin are seen.