Patients with positive anti-GP210 antibodies are often considered to have autoimmune hepatitis.A positive GP210 antibody value indicates that the patient has primary biliary cirrhosis. For this type of patient, both antinuclear and antimitochondrial antibodies are positive, but some patients may be negative for mitochondrial antibodies and positive for GP210 antibodies. At this point, the patient should be suspected of having primary biliary cirrhosis, and ultrasound-guided aspiration biopsy of liver tissue should be considered if necessary. Immunohistochemistry, if necessary, can diagnose the nature of the lesions through pathologic examination. If the diagnosis of autoimmune hepatitis and primary biliary cirrhosis is confirmed, oral treatment with ursodeoxycholic acid (UXF) should be considered. Patients need to take Yusifo for a long time and take regular blood tests for routine blood tests and liver function tests.