If the palms of the hands are too red and the size of the palms of both hands is too red, it can not be ruled out due to liver palms, which are usually seen in patients with chronic viral hepatitis and patients with chronic hepatitis, including viral hepatitis and autoimmune hepatitis patients. In addition, for patients with cirrhosis of the liver may also appear liver palms. Therefore, for patients with red palms, blood should be drawn for hepatitis B and hepatitis C related tests, such as hepatitis B triple system and hepatitis C antibodies. If the patient’s examination suggests viral hepatitis B or C, blood should also be drawn to check for hepatitis B DNA virus and hepatitis C RNA virus to see if the patient has any replication of the virus. If there is viral replication, and combined with elevated ghrelin and ghrelin transaminases, active antiviral therapy should be considered if necessary, including oral tenofovir, entecavir, and interferon injections for further treatment. In addition, the patient should have an ultrasound and, if necessary, a gastroscopy to look for the possibility of cirrhosis and hypersplenism.