High bicarbonate is usually not a kidney problem. Bicarbonate is an important indicator in blood gas analysis, mostly used to reflect the acid-base balance in the body, and when bicarbonate is high, it may be caused by too much alkaline substances in the body or alkalosis. Patients with kidney problems are recommended to go to the hospital for timely examination and symptomatic treatment after clear diagnosis. If the patient causes hyperventilation in the body due to emotional anxiety, stress, or high fever or hyperthyroidism, it may lead to respiratory alkalosis, when the bicarbonate will be high. In contrast, kidney problems may lead to excessive acidity in the body and metabolic acidosis. At this time, the acid combined with bicarbonate can be turned into carbon dioxide and water and excreted out of the body, while reducing the acidic environment in the stomach and maintaining the body’s balance, so patients with kidney problems may have low bicarbonate instead of high bicarbonate. In addition, if there is a manifestation of acidosis in the body, the respiratory system may reduce the acidic environment in the body by hyperventilation, so a high bicarbonate may develop in order to suppress acidosis, but a high bicarbonate does not clearly indicate that there is a kidney problem. Therefore, if there is a problem with the kidneys, it is recommended to go to the hospital for timely examination, such as taking blood tests and testing urine routine for judgment. When the urea nitrogen creatinine ratio is detected, especially when creatinine is elevated, it is necessary to consider whether there is a kidney problem, that is, renal insufficiency, and serious renal insufficiency may lead to kidney failure and even uremia. In the treatment, it needs to be controlled by hemodialysis, hemofiltration, and may even need kidney replacement treatment.