Low glomerular filtration rate and high creatinine usually indicate the presence of glomerular pathology such as nephritis, nephrotic syndrome, etc., which need to be treated with medication according to the cause. 1. Nephritis: including acute glomerulonephritis, chronic glomerulonephritis, lupus nephritis, etc., which will cause low glomerular filtration rate and high creatinine. Patients need to follow the doctor’s instructions to take drugs to reduce edema such as hydrochlorothiazide, furosemide, urinary protein-lowering, antihypertensive drugs such as enalapril, benazepril, etc., immunosuppressants such as hydroxychloroquine, cyclophosphamide, etc., antiplatelet or anticoagulant drugs such as low molecular heparin, warfarin and so on. 2. Nephrotic syndrome: the glomerular filtration rate decreases to below 50% of normal, and the concentration of urea and creatinine in plasma increases. Patients can take glucocorticoids such as prednisone, cytotoxic drugs such as cyclophosphamide, nitrogen mustard hydrochloride, etc., cyclosporine for treatment according to the condition. Low glomerular filtration rate and high creatinine may also have other causes, it is recommended to consult a doctor in time and take appropriate treatment according to medical advice.