Foot swelling after 40 days of intramedullary nail fixation surgery for femur fracture can be targeted for general treatment, physical therapy treatment, medication, and surgical treatment. It is mostly seen in poor blood circulation, deep vein thrombosis of the lower limbs, and so on. 1. Poor blood circulation: mainly caused by long-term inactivity, the affected limbs can be properly elevated, can effectively promote blood circulation, relieve the swelling symptoms, if necessary, can be appropriate oral blood stasis medication, such as Shujinhuaixu tablets, compound panax ginseng capsule and so on. 2. Lower extremity deep vein thrombosis: it is mainly caused by blood coagulation in the lower extremity deep vein system, oral anticoagulant drugs can be taken, such as aspirin, clopidogrel, etc. If the lower extremity deep vein thrombosis is more serious, it is necessary to take inferior vena cava filter implantation treatment. Femur fracture intramedullary nail fixation surgery 40 days after the foot swelling may also be caused by other reasons, if a long time does not relieve, it is recommended to go to the hospital in a timely manner to improve the examination, to clarify the cause of compliance with the doctor’s instructions for targeted treatment or treatment, do not blindly use their own medication, so as not to delay the condition.