Discomfort in systemic conditions, such as endocrine, metabolic disorders, vitamin B deficiency and other causes, especially menopausal women often complain of irregular tongue pain. So, what examination items should be done for patients with painful red tongue? The following is a brief introduction: 1, blood routine, blood test is the blood of the formed fraction that is red blood cells, white blood cells and platelets of the three systems of quantitative and qualitative testing and analysis. Any pathological changes in the blood will affect the tissues and organs of the whole body; conversely, lesions in tissues or organs can cause changes in the blood components, thus hematological analysis and its results are of great help in understanding the severity of the disease. 2, oral endoscopy, the emergence of oral endoscopy, for the oral aspects of the examination and treatment brought a new model, when the patient’s lesion scene is displayed in front of the patient, without more description or expertise. Patients can also understand the urgency of treatment. The physician can further discover the patient’s oral lesions with the aid of clear and visual images, and various treatment measures taken in a timely manner. 3, oral visual examination is sufficient, if the oral ulcer has a long duration or is a concomitant symptom of other diseases, the primary disease should also be examined.