The clinical symptoms of acromegaly often manifest as prominent forehead and zygomatic bones. Acromegaly is an abnormal hyperplastic disorder of the skin and bones caused by excessive secretion of growth hormone from the pituitary gland due to hyperplasia or tumors. So, how should a patient with forehead and cheekbone protrusion be diagnosed? The following is a brief introduction: acromegaly causes forehead and zygomatic protrusion symptoms, slow onset, headache, vision loss, visual field loss, special facial features: enlarged jaw, forehead and zygomatic protrusion, thick lips, large nose, large tongue, coarse face, thickening of the face; hand and foot acromegaly. In the early stage of the disease (formative stage), there is generalized hypertrophy of the physique and viscera and hyperfunction of the anterior pituitary gland; in the late stage (recessionary stage), there is physical decline and secondary hypopituitarism. 1, the disease is rare, mostly occurs in young and middle-aged men, the average age of onset is 40 to 45 years. The onset of the disease is generally slow and the duration of the disease is long, up to more than 30 years. 2. GH adenoma of childhood onset is characterized by gigantism; adult onset is mainly characterized by occupational effects and endocrine disorders, such as coarse facial features, headache and weakness, excessive sweating, back pain, widening and enlargement of hands and feet, increasing hat and shoe size, and signs and symptoms of diabetes and hyperthyroidism.