Pressure pain in the middle of the spine back pain consider lumbar muscle strain, ankylosing spondylitis, supraspinous ligamentitis, lumbar intervertebral disc herniation. 1. lumbar muscle strain, usually occurs in often sedentary or long standing, often stooping work, can cause interspinous ligament strain and lumbar muscle strain on both sides, aseptic inflammation occurs, so there will be pressure and pain, through the rest, the line massage, relaxation of the local muscle symptoms can be reduced. 2. Ankylosing spondylitis, because of spinal hyperplasia, neighboring vertebrae grow together, which will cause limited spinal activity, stiffness, pressure pain in the middle of the spine, lumbar pain, can be clearly diagnosed by taking spinal films. It can be relieved by applying non-steroidal anti-inflammatory drugs or biological agents. 3. Supraspinous ligamentitis, pain in the center of the spine, obvious pressure pain on the spinous process, pain when bending. 4. Lumbar disc herniation, the nucleus pulposus protrudes to the center and compresses the nerves, which can cause pressure pain in the middle of the spine and back pain. The pressure pain in the middle of the spine and back pain persist without relief should be timely medical treatment, targeted treatment.