Hemolytic disease, also known as hemolytic anemia, is not usually caused by diarrhea. Hemolytic anemia is mainly caused by the destruction of red blood cells at a rate that exceeds the bone marrow’s ability to compensate for the damage, and it is not related to diarrhea, so diarrhea usually does not cause the disease. Hemolytic anemia is associated with a variety of causes, including abnormalities in the red blood cells themselves, immune abnormalities, malignant sepsis or hypertension, extensive burns, protozoal or bacterial infections, and chemical substances. There are different types of hemolytic anemia and specific symptoms. Chronic hemolytic anemia is characterized by jaundice, anemia and splenomegaly. Acute hemolytic anemia is characterized by chills and fever, abdominal pain and vomiting, hemoglobinuria, jaundice, and severe anemia. The disease, if left untreated, may cause complications such as acute renal failure, peripheral circulatory failure, and hepatic impairment. In order to prevent complications and alleviate pain, patients need to actively cooperate with doctors for treatment, and repeated diarrhea should be promptly consulted to clarify the cause of the disease and standardize the diagnosis and treatment under the guidance of doctors.