Respiratory alkalosis combined with metabolic acidosis first need to deal with the primary disease, such as lung infection need anti-inflammatory treatment; respiratory alkalosis given oxygen therapy, generally do not need special treatment; metabolic acidosis to keep the PH value in a relatively normal range, PH greater than 7.2 do not need treatment. PH less than 7.2 given sodium bicarbonate to correct acidosis. Respiratory alkalosis with inappropriately decreasing bicarbonate or metabolic acidosis with inappropriately decreasing partial pressure of carbon dioxide is diagnosed as respiratory alkalosis combined with metabolic acidosis. Treatment first needs to deal with the primary disease: for example, shock, chronic obstructive pulmonary disease, hypoxia, infection, etc. If the primary disease is treated in time, the acid-base imbalance tends to return to normal, such as bacterial infections require the use of cephalosporin, amoxicillin and other anti-inflammatory drugs. Respiratory alkalosis treatment is mainly to correct hypoxia and other symptomatic treatment; metabolic acidosis treatment of primary disease and the basis of attention to maintain the PH value in the normal range, to avoid acidemia on the patient’s harm. Mild metabolic acidosis (PH greater than 7.2) does not require supplementation of alkaline drugs. pH less than 7.2, a one-time supplementation of sodium bicarbonate, and then adjust the treatment according to the results of blood gas analysis. Acid-base imbalance is usually accompanied by electrolyte disorders, check the blood gas analysis at the same time need to pay attention to the ion level, timely correction of electrolyte disorders. Promptly consult a doctor and follow the doctor’s instructions for appropriate treatment.