Mouth ulcers are associated with external stimuli, decreased immune function, and micronutrient deficiencies. Oral ulcers appear pain its treatment method is similar, can take painkillers, anti-inflammatory drugs, promote healing drugs, etc. for treatment. 1. Painkillers: If the pain is severe, you can take oral diclofenac sodium extended-release tablets, loxoprofen sodium capsules and other drugs to relieve pain. 2. Anti-inflammatory drugs: when mouth ulcers are painful, anti-inflammatory drugs should be used, such as cediriodine tablets, quinclorac tablets, etc. These drugs can be sterilized and anti-inflammatory and inhibit the spread of mouth ulcers, which can relieve the pain and cure the disease. 3. Promote healing drugs: in order to promote the growth of oral mucosa, accelerate the healing of ulcers, can be used externally recombinant human epidermal growth factor gel, recombinant bovine alkaline fibroblast growth factor gel and so on coated in the surface of the ulcers, to promote the healing of wounds, but also effective in relieving pain. With the symptoms of painful mouth ulcers, it is recommended that patients seek timely medical attention and follow the doctor’s instructions for medication to avoid delaying the condition. Blind self-medication should be avoided.