It used to be thought that patients with medically refractory epilepsy who could not undergo resection were suitable for vagus nerve stimulation. This is indeed how patients are clinically screened for vagus nerve stimulation. But in fact, vagus nerve stimulation can be applied to all patients with epilepsy. Why is vagus nerve stimulation reserved for the most difficult to treat patients with epilepsy? First of all, because vagus nerve stimulation treatment reduces or suppresses seizures by improving overall brain function, not by directly destroying the epileptic foci like surgery, so the effect of vagus nerve stimulation treatment is slow to appear, and as brain function and brain network improve, seizures will become less and less frequent. Therefore, theoretically, all types of epilepsy can be treated with vagus nerve stimulation. Second, vagus nerve stimulation treatment is a minimally invasive treatment. There is no need to risk craniotomy, such as cerebral hemorrhage, hemiplegia, aphasia, etc. Therefore, vagus nerve stimulation is a good option for patients with intractable epilepsy that are still helpless so far, if resection surgery is not possible. In the past, vagus nerve stimulation was done less because the stimulator was expensive, but now, with the development of the economy, the price of vagus nerve stimulator is gradually coming within the reach of everyone. Especially with the emergence of domestic vagus nerve stimulators, the price of the device has basically entered the ability of the general public to pay. With the improvement of these brain functions, the quality of life of epileptic patients has increased significantly, and although some patients still have seizures, the satisfaction of patients and families is generally high. Therefore, vagus nerve stimulation therapy is an excellent method for treating epilepsy and improving brain function. It can be used both as a last secret weapon in refractory epilepsy and as a routine option to improve epilepsy and brain function.