According to the World Health Organization (WHO), about 70% of patients with malignant tumors should receive radiotherapy at various times. Forty-five percent of tumor cases are curable, of which 22% are surgical, 18% are radiotherapy and 5% are chemotherapy. More than 50% of patients with tumors are not curable and have unsatisfactory results with one of the available treatments. Comprehensive treatment, that is, according to the patient’s physical condition, pathological type, invasion range (disease stage) and development trend of tumor, reasonably and systematically apply the existing treatment tools in an integrated manner, in order to increase the cure rate and improve the quality of life of patients. This is currently the most important aspect of improving the efficacy of cancer and is well recognized. It is gratifying to note that during the last 20 years, the technology of radiation therapy for oncology has undergone dramatic changes. With the use of stereotactic radiotherapy (r-knife and X-knife) and three-dimensional conformal radiotherapy in clinical practice, the status and role of radiation therapy has fundamentally changed. Focused irradiation of lesions from multiple angles and directions in three-dimensional space can achieve treatment effects similar to surgical procedures in clinical practice. In this regard, our department has carried out multidisciplinary collaboration with many units and departments inside and outside the hospital, i.e., the comprehensive treatment of tumors. We have carried out research on the study of intensity-modulated radiotherapy external radiation border after breast-conserving surgery for breast cancer, the study of anus-conserving treatment for rectal cancer, as well as research on gallbladder cancer, gastric cancer, prostate cancer, etc., with remarkable efficacy. Not only the local control rate of tumor is improved, but also the side effects of patients are much lower than the general conventional radiation therapy. In addition, our department has also conducted research on radiation therapy for many benign diseases. Such as: scar irradiation, skin hemangioma irradiation, pigmentation choroidal nodular synovitis irradiation and so on. All of the above have achieved satisfactory results and even unexpected results for the patients. A large number of clinical practice proves that the survival rate of the former is much lower than that of the latter for single treatment and comprehensive treatment. Multidisciplinary comprehensive treatment can take the advantages of various treatments and is more beneficial to the improvement of quality of life. Only through purposeful and planned comprehensive treatment can we consolidate the efficacy, reduce recurrence, improve the cure rate, and also enable some of the mid- to late-stage cases or post-operative recurrence cases to be effectively controlled. The treatment of malignant tumors must take the path of comprehensive treatment.